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Modafinil (Modafinil) is a powerful nootropic and eugeroid (promoting wakefulness) drug. It is very popular among managers and students who need to improve their own productivity and efficiency. However, like any other stimulant, modafinil can have some side effects.

Even though modafinil is a prescription drug in many parts of the world, many people take it for more than just a doctor’s prescription. Millions of people on the planet drink these pills to increase the level of dopamine in their bodies, and with it, productivity and attention.

For many, this medicine helps to adapt more easily when changing time zones. For example, instead of feeling overwhelmed all day after a flight, a person can take modafinil. When the drug expires, it will be night in the new time zone and you can go to bed.

Some side effects of modafinil are more serious than others. You may experience mood swings while taking this medication, which include feelings of depression, an exaggerated sense of well-being, or extreme nervousness. These mood swings may also be accompanied by suicidal acts or thoughts. Some may develop allergic reactions, which often include swelling of the mouth, neck, or face, difficulty swallowing or breathing, and a feeling of tightness in the chest.

Other serious side effects of modafinil may include prolonged muscle spasms, chest pain associated with a fast heartbeat or unusually high blood pressure, and blood in the urine. Some may also experience yellowing of the eyes or skin, skin irritations such as peeling or blistering, or a feeling of confusion. In some cases, people may develop addiction, and this may represent a frequent desire to increase the dosage of medications. If any of these side effects occur or become persistent, it is important to speak with a healthcare professional.

Side Effect of Modafinil


Also known as sinus pressure. According to most of the researches done on Modafinil, this is the most commonly reported short-term effect, and its due to increased stimulation and production of two neurotransmitters used in increased wakefulness, which includes glutamate and orexin. The overproduction of these neurotransmitters leads to migraines. Also, due to increased concentration rates provided by Provigil, users forget to drink water and sleep appropriately, and this causes dehydration and fatigue, which eventually leads to prolonged headaches.

Another common side effect of modafinil is headaches. However, it should be noted that this symptom does not appear in everyone, although it is very common. There can be many reasons for this condition. But the most likely experts consider an increase in the level of the neurotransmitter glutamate. An increase in the concentration of this substance in the brain occurs against the background of an increase in the levels of dopamine and orexin.

Glutamate levels are more active in the brains of people suffering from anxiety or obsessive-compulsive disorder. Another possible cause of headaches with modafinil is dehydration. The fact is that many at the peak of activity, having earned money, forget to drink enough liquid during the day. And dehydration often leads to headaches. Lack of appetite Appetite disturbance, as a side effect of modafinil, is not a big problem when it comes to people who take the drug occasionally. But if we are talking about people who drink these pills every day, then the symptom must be fought. The stimulant effect of modafinil affects the central nervous system, which can lead to a decrease in appetite.

Many users report that on the day they take Modafinil, they can safely go without food without even noticing it. The feeling of hunger in them appears only when the effect of the drug weakens. If this is repeated every day, then health problems are unlikely to be avoided. In order for the body to produce enough neurotransmitters, blood cells, and other important compounds, it needs food. If the body does not receive enough food for a certain time, failures will begin in all systems, and the absorption of modafinil will also be disturbed.


Loss of coordination

Associated with anxiety and nervousness, especially in users with a positive history in the usage of nootropic drugs. According to the U.S. National Library of Medicine, most users, after 7-9hours, experience a certain level of anxiety. However, this level of anxiety differs in various users. Some users do not have the capability of taking many doses of Provigil as it causes a lack of coordination, while others can take as much as 200 mg of Provigil without anxiety.

Loss of coordination

Increased Awareness

At first, this is a positive sign of Provigil as this leads to mental enhancement and higher cognitive pre-processing, but increased awareness for over lots of hours takes a down-turn as it becomes very difficult to relax afterward, leading to hallucinations and other negative symptoms.

Increased Awareness


Modafinil is an anti-sleeping medication, and it keeps one awake for long periods; lack of sleep and disruption of the normal sleep-wake cycle can lead to the triggering of the onset of mental health issues. Also, the brain needs lots of rest for its normal functions, and because of the lack of adequate rest, Provigil induces a negative effect on the brain, causing mental stress.


Diarrhea and mild gastrointestinal discomfort may also occur with modafinil. The reason for this condition may be the slow breakdown of the active substance, which causes irritation in the intestinal tract. In addition, modafinil-activated “fight and flight system” can stimulate the lower intestines in some people, which in turn causes diarrhea. Anxiety In people suffering from anxiety, there is a higher activity of neurostimulators in the brain. This is especially true of norepinephrine, which is activated in the brain of an agitated person. As a result, if an agitated person takes modafinil, their symptoms are further exacerbated. Brain activity can be measured using an electroencephalogram. The human brain has alpha, theta and beta waves. By measuring their activity, you can determine the general mental state at a certain moment. This diagnostic method is often used by researchers to determine how different substances affect the brain. Anxiety states are usually associated with low alpha wave activity and, conversely, excessively high beta wave activity.


Insomnia is the most common side effect of modafinil. And there is logic in this, given that this tool is just the same intended to enhance wakefulness. Therefore, if at the moment when it is time to go to bed, the concentration of the active substance in the blood remains quite high, then, of course, you will not be able to fall asleep. This is a direct result of increased concentrations of orexin, histamine, and norepinephrine in brain cells. How to avoid it Most often, insomnia occurs due to the fact that modafinil was taken shortly before the evening. It is important to consider that, penetrating into the body, this substance continues to act for 10-12 hours. Therefore, to avoid insomnia at night, modafinil should be taken in the morning or at least 10 hours before the scheduled rest time. It is also important to avoid other stimulants when taking modafinil so that their effects do not overlap, enhancing the effect.

Dry mouth

This is another nasty side effect of modafinil. Dry mouth is the result of overstimulation of the nervous system. Norepinephrine, activated by modafinil, in turn acts on muscarinic receptors, and they stop the production of secrets of the digestive system, including saliva. In this way, the body conserves energy so that more energy goes to the muscles and brain (a typical manifestation of the “fight or flight” response).

When the body stops producing saliva, dry mouth occurs. If this is a temporary phenomenon, then there is no problem. The same cannot be said for people who take modafinil on a regular basis and experience this side effect also on a regular basis.

Persistent dry mouth can cause ulcers, as well as digestive problems (diarrhea or constipation).

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